2025/03/10 by Ana Trebše, Samo Roškar, Anže Mihelič +1 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Diphtheria, Corynebacterium, and Tetanus #Orthopaedic implants and arthroplasty #Orthopedic Infections and Treatments
paper · pdf · doi:10.1093/ofid/ofaf146
openalex publication_date 2025/03/10 · openalex created_date 2025/03/11 · openalex updated_date 2026/07/30
Background: spp. was the causative organism (CPJI), treated according to an institutional algorithm based upon European Bone and Joint Infection Society guidelines. Methods: From the institutional bone infection registry, 44 patients treated for CPJI between 2007 and 2023 were identified. CPJIs were divided into 2 groups according to the isolated microbes: monomicrobial (14 [32%]) and polymicrobial (30 [68%]). Patients were treated with debridement, antibiotics, and implant retention (DAIR; 14 [32%]) or with 1- or 2-stage implant exchange (reimplantation group; 30 [68%]). In 13 (30%) cases, antibiotic combination with rifampicin was used. Results: Out of 44 patients, 4 required further treatment. In monomicrobial CPJI, the treatment course was successful in all patients, whereas in polymicrobial CPJI it was successful in 87%. Antibiotic combination including rifampicin was used in 4 monomicrobial cases (29%) and 9 polymicrobial (30%) cases. In the polymicrobial group, DAIR was successful in 90% (9/10), while the reimplantation group had an 85% (17/20) success rate. Conclusions: In contrast with the previously published papers on CPJI, the results in our cohort were good, with the total cure rate being 91%. The cure rate was slightly lower in the polymicrobial group compared with the monomicrobial: 87% and 100%, respectively. Surgical therapy according to the established institutional algorithm resulted in a high success rate.