2023/01/11 by Erik S. Pena, Liubov M. Lifshits, Meital Eckshtain‐Levi +2 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Dendrimers and Hyperbranched Polymers #Metal-Organic Frameworks: Synthesis and Applications #RNA Interference and Gene Delivery
paper · pdf · doi:10.1002/wnan.1877
openalex publication_date 2023/01/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Metal-organic coordination polymers (CPs) are a broad class of materials that include metal-organic frameworks (MOFs). CPs are highly ordered crystalline materials that are composed of metal ions (or metal ion clusters) and multidentate organic ligands that serve as linkers. One-, two-, and three-dimensional CPs can be formed, with 2D and 3D structures referred to as MOFs. CPs have gained a lot of attention due to attractive structural features like structure versatility and tunability, and well-defined pores that enable the encapsulation of cargo. Further, CPs show a lot of promise for drug delivery applications, but only a very limited number of CPs are currently being evaluated in clinical trials. In this review, we outlined features that are desired for CP-based drug delivery platform, and briefly described most relevant characterization techniques. We highlighted some of the recent efforts directed toward developing CP-based drug delivery platforms with the emphasis on vaccines against cancer, infectious diseases, and viruses. We hope this review will be a helpful guide for those interested in the design and evaluation of CP-based immunological drug delivery platforms. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.