Structural analysis, in vitro anti-tubercular activities, and in silico ADMET evaluation of ethyl 7-methoxy-3-(4-substituted benzoyl)indolizine-1-carboxylates

2025/01/01 by Rahul D. Nagdeve, Jyoti Swarup Thakur, Sandeep Chandrashekharappa +9 · 1 voice
Chemistry · #Synthesis and Reactions of Organic Compounds #Synthesis and Reactivity of Heterocycles #Synthesis and pharmacology of benzodiazepine derivatives

paper · doi:10.1039/d4ce01018c

openalex publication_date 2025/01/01 · openalex created_date 2025/01/10 · openalex updated_date 2026/07/30

Abstract

A series of indolizine derivatives were synthesized and characterized by SC-XRD and computational analysis to investigate their structural aspects, as well as their anti-tubercular activity, with varying substituents.

Citations

• Mercury CSD 2.0– new features for the visualization and investigation of crystal structures
• ORTEP-3 for Windows - a version ofORTEP-III with a Graphical User Interface (GUI)
• OLEX2: a complete structure solution, refinement and analysis program
• Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
• CrystalExplorer: a program for Hirshfeld surface analysis, visualization and quantitative analysis of molecular crystals

Discussions

• Check out the HOT article by KN Venugopala, SK Nayak & co on structural analysis, in vitro anti-tubercular activities, and in silico ADMET evaluation of ethyl 7-methoxy-3-(4-substituted benzoyl)indoli [bsky, 1 points, 0 comments]

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