2025/04/10 by C Chedal-Anglay, William Vindrios · 1 voice
Immunology and Microbiology · Medicine · #Bacterial Infections and Vaccines #Blood groups and transfusion #Complement system in diseases
paper · pdf · doi:10.1093/ofid/ofaf223
openalex publication_date 2025/04/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
We present a unique case involving a patient who was diagnosed with X-linked properdin deficiency after 2 episodes of disseminated gonococcal infections 1 year apart. Although this deficiency is well-documented for its association with meningococcemia, its correlation with disseminated gonococcal infections (DGI) has not been previously reported. Recurrent DGI cases reported in the literature with identified cause are mostly associated with acquired or congenital complement pathway deficiencies. However, properdin deficiency is rarely screened for during a first episode. Our case not only highlights the clinical presentation that should raise suspicion of DGI but also underscores the importance of investigating the alternative complement pathway in such cases. At a time when gonococcal resistance is increasing, it is essential to consider existing strategies for preventing these infections, including vaccinations.