Ultrasound activates mechanosensitive TRAAK K + channels through the lipid membrane

2021/02/04 by Ben Sorum, Robert A. Rietmeijer, Karthika Gopakumar +2 · 1 voice · 6 citations
Engineering · Materials Science · Medicine · #Ultrasound Imaging and Elastography #Ultrasound and Cavitation Phenomena #Ultrasound and Hyperthermia Applications

paper · pdf · doi:10.1073/pnas.2006980118

openalex publication_date 2021/02/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/09

Abstract

channel TRAAK with submillisecond kinetics to an extent comparable to canonical mechanical activation. Single-channel recordings reveal a common basis for ultrasonic and mechanical activation with stimulus-graded destabilization of long-duration closures and promotion of full conductance openings. Ultrasonic energy is transduced to TRAAK through the membrane in the absence of other cellular components, likely increasing membrane tension to promote channel opening. We further demonstrate ultrasonic modulation of neuronally expressed TRAAK. These results suggest mechanosensitive channels underlie physiological responses to ultrasound and could serve as sonogenetic actuators for acoustic neuromodulation of genetically targeted cells.

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• Ultrasound isn't just for imaging—it's a powerful tool for modulating brain activity. Dr Ben Sorum explores how focused ultrasound could unlock new frontiers in neuroscience and therapy. doi.org/10.10 [bsky, 1 points, 0 comments]

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