Sustained Effectiveness of Doxycycline Post-Exposure-Prophylaxis in a Large Sexual Health Clinic Over 96 Weeks: An Interrupted Time Series Analysis

2025/05/06 by Matthew A. Spinelli, Megan J. Heise, Jorge Román +4 · 1 voice
Immunology and Microbiology · Medicine · #HIV, Drug Use, Sexual Risk #Reproductive tract infections research #Syphilis Diagnosis and Treatment

paper · doi:10.1093/cid/ciaf234

openalex publication_date 2025/05/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Doxycycline post-exposure prophylaxis (doxy-PEP) reduced bacterial sexually transmitted infection (STI) incidence in a sexual health clinic over 96 weeks (N = 4592; 2524 on doxy-PEP), particularly for chlamydia and syphilis, with smaller effects for gonorrhea. Continued surveillance for gonorrhea and antibiotic resistance is essential to evaluate doxy-PEP's long-term effectiveness.

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