2024/06/21 by Robert J. Stanton, Yasmin Aziz, Heidi Sucharew +18 · 1 voice
Economics, Econometrics and Finance · Medicine · #Biomedical Ethics and Regulation #Ethics in Clinical Research #Health Systems, Economic Evaluations, Quality of Life
paper · pdf · doi:10.1161/jaha.124.035102
openalex publication_date 2024/06/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
linical trials are essential to advancing medicine, bringing therapies from the bench to patients.The population that is enrolled within any randomized controlled trial is in large part a result of the inclusion and exclusion criteria chosen by the investigators.Women and minorities unfortunately remain underrepresented within clinical trials. 1 We sought to investigate the potential impact that common exclusion criteria by race and sex have on trial eligibility of patients with ischemic stroke within the GCNKSS (Greater Cincinnati/ Northern Kentucky Stroke Study) population.Data supporting this study are available from the corresponding author upon reasonable request.The GCNKSS is a population-based study of 1.3 million people living within the 5-county area surrounding Cincinnati.Between July 1, 2014 and December 31, 2015 for Black individuals and January 1, 2015 to December 31, 2015 for White individuals, we ascertained all hospitalized ischemic strokes by screening International Classification of Diseases, Ninth Revision (ICD-9) codes 430-436 and ICD-10 codes I60-I68 and G45-56.Institutional Review Board approval was obtained at all hospitals included; informed consent was waived because the study was retrospective.Race and sex were obtained through the electronic medical record.