2025/05/29 by Maria Lopopolo, Charlotte Avanzi, Sebastián Duchêne +51 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Leprosy Research and Treatment #Mycobacterium research and diagnosis #Yersinia bacterium, plague, ectoparasites research
paper · doi:10.1126/science.adu7144
openalex publication_date 2025/05/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Leprosy, caused primarily by Mycobacterium leprae , is considered a disease introduced into the Americas during European colonization. However, the recent discovery of a second pathogen causing leprosy, M. lepromatosis , mainly found in the Americas, challenges this view. Here, we show that M. lepromatosis infected humans in the Americas before European contact. By screening 389 ancient and 408 contemporary samples, we have expanded the genetic data available for the species. Phylogenetic analyses revealed distinct human-infecting clades of M. lepromatosis , with one dominating North America since colonial times. The presence of millennia-old strains in North and South America indicates that M. lepromatosis may have been widespread during the Late Holocene, demonstrating that M. lepromatosis leprosy has a long-standing history in the Americas before European arrival.