2025/06/12 by Jennifer Ross, William Sieling, Kaylyn N. Billmeyer +4 · 2 voices · 1 citation
Immunology and Microbiology · Medicine · #Antibiotic Use and Resistance #Antibiotics Pharmacokinetics and Efficacy #Surgical site infection prevention
paper · pdf · doi:10.1093/ofid/ofaf343
openalex publication_date 2025/06/12 · openalex created_date 2025/06/13 · openalex updated_date 2026/07/30
Background: Outpatient parenteral antimicrobial therapy (OPAT) is a mechanism for delivery of antimicrobial therapy outside of inpatient care; however, risks associated with OPAT combined with transition-of-care vulnerabilities may result in unscheduled healthcare use. On 15 June 2020, our institution launched a program entailing OPAT plan review and reconciliation by infectious diseases (ID) pharmacists prior to hospital discharge. We analyzed the frequency of all-cause 90-day emergency department (ED) visits, readmissions, and mortality of patients pre- and postimplementation of OPAT plan reconciliation. Methods: Unique, adult OPAT recipients discharged to home or a postacute care facility from an academic hospital before (1 June 2017-14 June 2020) and after (15 June 2020-30 June 2022) implementation of ID pharmacist review and reconciliation of OPAT plans were included. We performed a propensity score-weighted analysis to compare 90-day outcomes pre- and postintervention while adjusting for relevant clinical characteristics. We accounted for missing data by using multiple imputation. Results: = .01) within 90 days after discharge from index admission when compared to the preimplementation cohort. There was no significant difference in the 90-day all-cause mortality between cohorts. Conclusions: Following implementation of OPAT plan reconciliation by ID pharmacists prior to discharge from acute care, OPAT recipients were significantly less likely to experience 90-day ED visits or 90-day readmissions.