2025/07/07 by K.E. Johnston, Kate O’Connell, Veronica McSharry +11 · 1 voice
Medicine · #Cancer survivorship and care #Nutrition and Health in Aging #Childhood Cancer Survivors' Quality of Life
paper · pdf · doi:10.12688/hrbopenres.14187.1
openalex publication_date 2025/07/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
<ns3:p>Background To align with the EU Beating Cancer Plan, feasible and innovative solutions that monitor specific needs of cancer survivors, improve quality of life and long-term disease-free survival need to be investigated. The Linking You to Support and Advice (LYSA) Trial was a multisite, randomized feasibility trial, co-designed with public and patient involvement. Eligible participants had early-stage hormone receptor (HR)-positive breast or gynaecologic cancer, completed primary curative treatment within 12 months and had internet access (NCT05035173). The 12-month intervention involved a dietitian and nurse-led clinic targeting symptom management. Detailed protocols targeted towards dietetic services and interventions are limited in this cohort. The dietetic component of the LYSA Trial aims to evaluate the impact of using electronic patient reported outcomes (ePROs) on diet quality and body composition in HR-positive breast and gynaecologic cancer survivors. Over 12 months, changes in dietary intake, nutritional risk, body weight, lean tissue mass, adipose tissue mass and muscle strength will be assessed. Methods Comprehensive anthropometric and nutritional assessments were conducted at baseline and 12 months for both study arms. These included body composition through bioelectrical impedance analysis and World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) diet quality score. Participants in the experimental arm completed ePROs every 2 months for one year, assessing malnutrition risk, physical activity and weight gain concerns. A trigger-initiated nutritional management pathway, delivered via a telehealth platform was developed for worsening or severe individualised symptoms. Conclusion This protocol outlines the implementation of a dietetic cancer survivorship clinic, within a randomised control trial. The use of ePROs and digital technologies offers viable and innovative solutions to monitor the nutrition-specific needs of cancer survivors. Findings will inform the development of future dietetic survivorship services. Trial registration ClinicalTrials.gov , NCT05035173 . Retrospectively registered on September 5, 2021. Registered on OSF: doi:<ns3:ext-link xmlns:ns4="http://www.w3.org/1999/xlink" ext-link-type="uri" ns4:href="http://dx.doi.org/10.17605/OSF.IO/JM7FX">10.17605/OSF.IO/JM7FX</ns3:ext-link>.</ns3:p>