2025/05/17 by Daniel Konrad, Àngela Vidal, Janna Pape +1 · 1 voice
Medicine · #Ovarian function and disorders #Reproductive Biology and Fertility
paper · pdf · doi:10.1016/j.rbmo.2025.105054
openalex publication_date 2025/05/17 · openalex created_date 2025/05/18 · openalex updated_date 2026/07/28
Anti-Müllerian hormone (AMH), produced by follicular granulosa cells, is a potential marker of granulosa cell function and may influence reproductive outcomes. A low concentration of AMH in follicular fluid (ffAMH) has been associated with granulosa cell dysfunction, but data on its association with the clinical pregnancy rate (CPR) after IVF remain limited and inconclusive. In order to address this research gap, the study question was formulated as follows: What is the association between ffAMH concentration and CPR after IVF? A systematic literature search was conducted in Medline, Embase and Cochrane databases until January 2024, including observational studies examining the association between ffAMH and CPR after IVF. Sixteen studies with 638 pregnant and 1069 non-pregnant women were analysed, encompassing both stimulated (95.1%) and non-stimulated (4.9%) IVF protocols. The meta-analysis revealed a significantly higher mean ffAMH concentration in pregnant women compared with non-pregnant women (standardized mean difference = 0.76, 95% CI 0.27-1.25; I² = 83%, P < 0.01). This finding suggests that ffAMH could serve as a marker for granulosa cell function and a potential indicator of oocyte quality. While ffAMH shows promise as a prognostic and selection marker for oocytes, the substantial heterogeneity across studies underscores the need for further research before clinical implementation.