2025/06/30 by Brandi M. Mize, Emily Laskey, Gregory L. Damhorst +2 · 1 voice
Medicine · Veterinary · #Brucella: diagnosis, epidemiology, treatment #Infectious Aortic and Vascular Conditions #Kawasaki Disease and Coronary Complications
paper · pdf · doi:10.1093/ofid/ofaf404
openalex publication_date 2025/06/30 · openalex created_date 2025/07/09 · openalex updated_date 2026/07/29
Abstract Brucella suis, a zoonotic pathogen, can affect multiple human organ systems causing various clinical manifestations. While aortoiliac involvement is rare worldwide, we report 2 cases of aortic brucellosis following abdominal aortic aneurysm repairs within a 9-year period at a single US institution in Georgia. One case was an infected aortic endograft, which may be the first reported. B suis aortoiliac infections are rare even in endemic areas, thus highlighting how uncommon these cases are in Georgia. Acknowledging the dismal prognosis with symptomatic aortic graft infections, we wish to share our experience in successfully treating them, including an infected aortic endograft. We recommend obtaining a robust history when evaluating individuals with suspected mycotic aneurysms who frequently handle animals. Education on protective equipment and proper handling of animals is imperative to reduce the risk of aortic graft brucellosis infections. Our institutional experience suggests that graft explantation and doxycycline-rifampin are acceptable treatment options.