2025/04/01 by Tania Verma, Gaurav S Manhas, Rameshwar S Manhas · 1 voice
Medicine · #Bladder and Urothelial Cancer Treatments #Pelvic floor disorders treatments #Urinary Tract Infections Management
paper · doi:10.4103/jmh.jmh_77_24
openalex publication_date 2025/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
A BSTRACT In this meta-analysis and systematic review, the effectiveness and safety of single-dose fosfomycin were evaluated in comparison to other antibiotics for treating uncomplicated urinary tract infections (UTIs) in women, including asymptomatic bacteriuria (ASB) in pregnant women. Two independent reviewers conducted an electronic search on until December 2023 to search for randomized controlled trials that studied the efficacy and safety of fosfomycin for management of uncomplicated UTI in women or ASB in pregnant women and included those that fulfilled the eligibility criteria. The results showed that single-dose fosfomycin was comparable with other antibiotic agents in clinical resolution of uncomplicated UTI (odds ratio [OR]: 1.11, 95% confidence interval [CI] 0.88–1.41, I 2 = 0%, P = 0.37, moderate certainty). Moreover, single-dose fosfomycin was equal to other antibiotics in the microbiological resolution of uncomplicated UTI (OR: 1.02, 95% CI: 0.83–1.25, I 2 = 34%, P = 0.88, moderate certainty) and ASB among nonpregnant women (OR: 0.76, 95% CI: 0.45–1.28, I 2 = 0%, P = 0.30, moderate certainty). The incidence of adverse events too was similar in patients receiving fosfomycin or other antibiotics (OR: 0.97, 95% CI: 0.77–1.23, I 2 = 41%, P = 0.82, moderate certainty). Administering a single dose of fosfomycin is just as safe and effective as other antibiotics in treating uncomplicated UTIs in women. Prescribing a single dose of fosfomycin (3 g) as a regular practice may result in higher compliance rates and a reduced likelihood of antibiotic resistance.