Dynamic Gene Expression Mitigates Mutational Escape in Lysis-Driven Bacteria Cancer Therapy

2024/01/01 by Filippo Liguori, Nicola Pellicciotta, Edoardo Milanetti +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Environmental Science · #Cancer Research and Treatments #Bacteriophages and microbial interactions #CRISPR and Genetic Engineering

paper · doi:10.34133/bdr.0049

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

gene better preserves the original population of therapeutic bacteria by mitigating the effects of mutational escape. Altogether, we demonstrate how dynamic modulation of gene expression can address mutant takeovers giving rise to limitations in engineered bacteria for therapeutic applications.

Citations

• GROMACS: A message-passing parallel molecular dynamics implementation
• LINCS: A linear constraint solver for molecular simulations
• Cellpose 2.0: how to train your own model

Discussions

• Optimized engineered bacteria for tumor therapy by dynamic gene control! #SyntheticBiology #CancerTherapy Details: doi.org/10.34133/bdr.0049 [bsky, 1 points, 0 comments]

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