A fluorogenic probe for screening aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors

2025/01/01 by Shilpendu Ghosh, Sayar Ghosh, Aniket Majee +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Alcohol Consumption and Health Effects #Cancer, Hypoxia, and Metabolism #Eicosanoids and Hypertension Pharmacology

paper · pdf · doi:10.1039/d5cc03947a

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21

Abstract

A green-emitting fluorogenic isatin–naphthalimide fluorophore inhibits ALDH1A1by binding in substrate cavity enabling evaluation of binding parameters to screen competitive inhibitors by standard fluorimeters aiding measurements and assay development.

Discussions

• 🚨📢Excited to share our work in @chemcomm.rsc.org A Fluorogenic Probe for Screening Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors. 🔗 doi.org/10.1039/D5CC... [bsky, 1 points, 0 comments]

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