2025/09/17 by Aidan T. Morrell, Ryland Kagan, Mackenzie C. Kelly +4 · 1 voice · 1 citation
Medicine · #COVID-19 Clinical Research Studies #COVID-19 and healthcare impacts #Venous Thromboembolism Diagnosis and Management
paper · pdf · doi:10.2340/17453674.2025.44481
openalex publication_date 2025/09/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
BACKGROUND AND PURPOSE: Limited data exist on venous thromboembolism (VTE) and mortality risk in patients undergoing primary total hip (THA) or knee arthroplasty (TKA) following recent COVID-19 infection. We aimed to evaluate whether the timing of COVID-19 infection affects postoperative VTE and mortality risk after THA or TKA. METHODS: Adult Kaiser Permanente Northern California members undergoing elective THA or TKA from 2020-2022 were identified using internal procedure codes. 33,520 patients with or without SARS-CoV-2 within 6 months preoperatively were compared. Multivariate Poisson regression was used to calculate incidence rate ratios (RRs) adjusted for demographics, comorbidities, and Covid vaccination status. The primary outcome was 90-day VTE (deep venous thrombosis or pulmonary embolism). The secondary outcome was 90-day mortality. RESULTS: Among patients with recent COVID-19, the 90-day VTE rate was 0.3%, and the mortality rate was 2.5%. Recent COVID-19 within 6 to 12 weeks preoperatively did not significantly increase 90-day VTE risk (RR 1.0, 95% confidence interval [CI] 0.38-2.8) but was associated with increased 90-day mortality risk (RR 3.1, CI 1.7-5.4). CONCLUSION: Recent COVID-19 infection did not significantly impact VTE risk after THA or TKA. However, infection within 6 to 12 weeks preoperatively was associated with increased 90-day mortality.