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Haploidentical Hematopoietic Stem-cell Transplant for High-Risk Acute Myeloid Leukemia in a Kidney Transplant Recipient: Case Report

2025/06/13 by Hércules Amorim Mota Segundo, Ana Vitória Magalhães Chaves, Thays Araújo Freire de Sá +4 · 1 voice
Medicine · #Acute Myeloid Leukemia Research #Chronic Myeloid Leukemia Treatments #Acute Lymphoblastic Leukemia research

paper · pdf · doi:10.46765/2675-374x.2025v6n1p264

openalex publication_date 2025/06/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Solid organ transplantation is associated with a higher incidence of malignancies. Among them, acute myeloid leukemia has high morbidity and mortality, and its cure is only possible through allogeneic hematopoietic stem cell transplantation for high-risk disease. Case report: A 32-year-old female who underwent a kidney transplant eight years before was diagnosed with high-risk acute myeloid leukemia. She underwent induction therapy with “7+3”, achieving complete remission with measurable residual disease detectable by flow cytometry. She then underwent a myeloablative haploidentical allogeneic transplant, achieving complete remission, free of graft-versus-host disease, with a functioning renal graft.

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