2025/09/12 by Shiyang Zhang, Cheng Xu, Chengyong Jia +8 · 1 voice
Environmental Science · #Effects and risks of endocrine disrupting chemicals
paper · doi:10.1016/j.eehl.2025.100185
openalex publication_date 2025/09/12 · openalex created_date 2025/10/16 · openalex updated_date 2026/07/23
= 0.03, 0.02, and 0.02, respectively] after multiple adjustment in Cox proportional hazard models. Meanwhile, linear associations for serum di-iso-butyl phthalate (DiBP), DnBP, ΣDBP, and ΣLMW, and a nonlinear U-shaped dose-response association for serum butyl-benzyl phthalate (BBP) with incident stroke risk were proved by restricted cubic spline regression analyses. Furthermore, a positive correlation between PAE mixture and incident stroke risk was identified in Quantile-based g-computation [HR (95%CI): 1.24 (1.05, 1.46)]. However, serum PAEs, either as individuals or as a mixture, were not associated with incident CVD or coronary heart disease risk. Our study revealed that serum PAEs were positively associated with increased incident stroke risk in the T2DM population. More prospective cohort and mechanism studies are warranted to validate our findings.