Selective labeling and visualization of viral and bacterial neuraminidases using ortho -quinone methide-based probes

2025/01/01 by Erianna I. Alvarado-Melendez, Simon T. Ruessink, Karin Strijbis +1 · 1 voice
Chemistry · Medicine · #Carbohydrate Chemistry and Synthesis #Click Chemistry and Applications #Influenza Virus Research Studies

paper · pdf · doi:10.1039/d5cb00170f

openalex publication_date 2025/01/01 · openalex created_date 2025/10/01 · openalex updated_date 2026/07/30

Abstract

strains at nanomolar concentrations. Moreover, we developed a strategy that significantly improves labeling specificity of NAs when using our probes in complex samples, addressing the common issue of nonspecific labeling associated with quinone methide-based probes. Additionally, we demonstrate the potential of these probes for imaging extracellular NAs on bacterial surfaces, highlighting their utility for studying NAs in their native environments.

Discussions

• Fresh from Tom Wennekes et al., from @utrechtuniversity.bsky.social New ortho-quinone methide probes selectively label viral and bacterial neuraminidases, enabling imaging of these key virulence enz [bsky, 1 points, 0 comments]

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