2025/11/26 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Developmental Biology and Gene Regulation #Pluripotent Stem Cells Research #Retinal Development and Disorders
paper · pdf · doi:10.1242/dev.205358
openalex publication_date 2025/11/26 · openalex created_date 2025/11/27 · openalex updated_date 2026/07/31
During mammalian eye development, Sox2 is involved in the gene regulatory network that helps retinal progenitor cells (RPCs) gain neural competence, but how it mechanistically contributes to this process is unclear. In a new study, Issam Al Diri and colleagues address this and unravel the chromatin-based functions of SOX2 in the developing retina. To learn more about this work and the people behind it, we talked to first authors Fuyun Bian, Kimiasadat Golestaneh, Emily Davis and Abdullah Khan from the Retinal Epigenetics and Genomics Laboratory at the UPMC Vision Institute, University of Pittsburgh, PA, USA.