Comparison of cefazolin administered as a continuous or intermittent infusion for prophylaxis of surgical site infections in adult patients undergoing cardiac or neurologic surgery

2025/12/03 by Richard H. Drew, Nicholas Turner, Elizabeth Keil +1 · 1 voice
Medicine · #Blood transfusion and management #Nosocomial Infections in ICU #Surgical site infection prevention

paper · pdf · doi:10.1017/ice.2025.10365

openalex created_date 2025/12/03 · openalex publication_date 2025/12/03 · openalex updated_date 2026/07/28

Abstract

Abstract In a propensity-matched cohort of adult cardiac or neurosurgical procedures ( n = 1,342), infection was less frequent with continuous infusion (1.8%) versus intermittent cefazolin (2.4%), though the difference was statistically non-significant (−0.6%, 95% CI−2.3 to 1.1; p = 0.57). The 0% infection rate among cardiac cases receiving continuous cefazolin infusion warrants further investigation.

Discussions

• NEW in ICHE: Authors used a propensity-matched cohort to evaluate intermittent vs. continuous cefazolin for SSI prevention in cardiac/neuro procedures🧠❤️ ▶️ While non-significant differences, 0% SS [bsky, 1 points, 0 comments]

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