Pressure-induced phase behaviour and compressibility of the racemic and chiral solid forms, ofloxacin and levofloxacin

2025/01/01 by Julia Gasol-Cardona, Martin R. Ward, Davide Comboni +5 · 1 voice
Chemistry · Earth and Planetary Sciences · Engineering · #Crystallography and molecular interactions #Energetic Materials and Combustion #High-pressure geophysics and materials

paper · pdf · doi:10.1039/d5ce00855g

openalex publication_date 2025/01/01 · openalex created_date 2025/10/30 · openalex updated_date 2026/07/02

Abstract

High-pressure crystallography of three related fluoroquinolone solid forms reveals distinct phase behaviour under compression providing understanding of API stability under processing conditions.

Citations

• <i>VESTA 3</i> for three-dimensional visualization of crystal, volumetric and morphology data
• <i>OLEX2</i>: a complete structure solution, refinement and analysis program
• <i>PASCal</i>: a principal axis strain calculator for thermal expansion and compressibility determination
• Hydrostatic limits of 11 pressure transmitting media

Discussions

• 🔓Check out the #OpenAccess work by Iain D. H. Oswald and co-workers reporting pressure-induced phase behaviour and compressibility of the racemic and chiral solid forms, ofloxacin and levofloxacin⬇️ [bsky, 1 points, 0 comments]

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