2025/06/28 by Mostafa Elshazly, Garuti Giancario, Benan Bayrakçı +3 · 1 voice
Medicine · #Inhalation and Respiratory Drug Delivery #Neonatal Respiratory Health Research #Respiratory Support and Mechanisms
paper · doi:10.4103/mgr.medgasres-d-24-00129
openalex publication_date 2025/06/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15
Noninvasive ventilation (NIV) and high-flow nasal cannula are increasingly used to treat acute respiratory failure. Because many of these patients could also benefit from inhaled medications, combining aerosol therapy with NIV or high-flow nasal cannula is a promising approach. Effective drug delivery to the lungs is crucial for successful aerosol therapy during NIV. Prior research has identified several factors that affect aerosol delivery efficiency in NIV patients. Medical gases have a long history of use in managing various respiratory conditions. Among them, oxygen is frequently used for patients with hypoxia (e.g., hypoxemic respiratory failure and in newborns). In addition to deoxygenation, helium oxygen mixture and nitric oxide can also be administered through devices such as masks combined with NIV. This narrative review aims to provide a comprehensive overview on the application of gas mixtures (such as helium oxygen mixtures and nitric oxide) in NIV, focusing on their efficacy, safety, and optimization strategies in different clinical settings.