2025/12/29 by Ivo Petrov, Kamen Stoichev, Okan Aliman +11 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Cardiovascular and exercise physiology #Exercise and Physiological Responses #Coenzyme Q10 studies and effects
paper · doi:10.1097/phm.0000000000002932
openalex publication_date 2025/12/29 · openalex created_date 2026/01/28 · openalex updated_date 2026/05/21
OBJECTIVE: To compare the effects of two nutritional supplementation strategies Amendcor® (Creatine, D-ribose, coenzyme Q10, and vitamin E) vs. Ubiquinol+D-ribose, combined with a 12-wk group-based high-intensity aerobic interval training (GB-HIAIT) on functional exercise capacity (FEC), health-related quality of life (HRQoL), left ventricular ejection fraction (LVEF), and perceived exertion (PE), in patients with heart failure with reduced ejection fraction (HFrEF). DESIGN: 68 patients with HFrEF were randomly assigned to a Creatine + D-ribose + CoQ10 + Vit. E) (n = 35) or a Ubiquinol + D-ribose group (n = 33) and performed GB-HIAIT. The primary outcome was FEC, assessed via the 6-minute walk test (6MWT), peak VO₂, and peak respiratory exchange ratio (RER). Secondary outcomes included HRQoL, LVEF, and PE. RESULTS: Study participants supplemented with Creatine + D-ribose + CoQ10 + Vit. E demonstrated significantly greater improvements in FEC (6MWT: +19.88%, VO₂ peak: +25.46%, PE: -38.53%), HRQoL: -25.64%, LVEF: +40.94%, compared with subjects supplemented with Ubiquinol + D-ribose (P < 0.05). CONCLUSIONS: Patients with HFrEF who received multi-ingredient supplementation combined with GB-HIAIT demonstrated superior improvements in FEC, HRQoL, LVEF, and PE, compared with those supplemented with Ubiquinol + D-ribose.