Porphyromonas gingivalis Induces Chronic Kidney Disease through Crosstalk between the NF-κB/NLRP3 Pathway and Ferroptosis in GMCs

2024/10/01 by Xue Li, Chao Yao, Dongmei Lan +4 · 1 voice
Biochemistry, Genetics and Molecular Biology · Dentistry · Medicine · #Ferroptosis and cancer prognosis #Inflammasome and immune disorders #Oral microbiology and periodontitis research

paper · doi:10.1007/s11596-024-2923-x

crossref issued 2024/10/01 · crossref published 2024/10/01 · crossref published-print 2024/10/01 · openalex publication_date 2024/10/01 · crossref published-online 2024/10/24 · crossref created 2024/10/24 · crossref deposited 2024/12/10 · openalex created_date 2025/10/10 · crossref indexed 2026/07/20 · openalex updated_date 2026/07/23

Citations

• The association of periodontal diseases with metabolic syndrome and obesity
• The prevalence and severity of periodontal disease in Mainland China: Data from the Fourth National Oral Health Survey (2015–2016)

Discussions

• This study shows that P. gingivalis induces #CKD in mice via #NFκB/#NLRP3 crosstalk & #Ferroptosis in #Mesangial cells, highlighting the contribution of #Periodontitis to CKD pathogenesis, underscorin [bsky, 1 points, 0 comments]