2021/09/13 by Vijayasankar Palaniappan, Raveendran Premjith, Kaliaperumal Karthikeyan · 1 voice
Medicine · #Tuberculosis Research and Epidemiology #Mycobacterium research and diagnosis #Diagnosis and treatment of tuberculosis
paper · pdf · doi:10.4269/ajtmh.21-0736
openalex publication_date 2021/09/13 · openalex created_date 2021/12/06 · openalex updated_date 2026/07/28
A 16-year-old Indian boy presented with an 8-year history of an asymptomatic, slowly progressive skin lesion over the left knee. Examination showed a single, well-defined erythematous scaly plaque with crusting, and areas of atrophy and scarring (Figure The patient's past medical history and family history were not significant. A tuberculin skin test was strongly positive (Figure Incisional biopsy revealed multiple well-formed epithelioid granulomas with or without giant cells surrounded by lymphocytic infiltrates in the dermis (Figure Ziehl-Neelson staining of the tissue section, mycobacterial culture of a tissue specimen, and polymerase chain reaction for Mycobacterium tuberculosis were negative. Based on the clinicopathologic findings, a diagnosis of lupus vulgaris was made. The patient was treated with antituberculous therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol) for 6 months. At the end FIGURE 1. (A) A 7.25 3 6.25-cm pear-shaped, well-defined erythematous scaly plaque with crusting and areas of atrophy and scarring. (B) Lesion resolved, with wrinkled atrophic scarring after treatment.