Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026

2026/03/23 by Hallie C. Prescott, Massimo Antonelli, Waleed Alhazzanic +66 · 1 voice
Medicine · Immunology and Microbiology · #Sepsis Diagnosis and Treatment #Nosocomial Infections in ICU #Immune Response and Inflammation

paper · pdf · doi:10.1007/s00134-026-08361-1

openalex publication_date 2026/03/23 · openalex created_date 2026/03/24 · openalex updated_date 2026/07/31

Abstract

Sepsis, life-threatening acute organ dysfunction due to infection [ 1 ], is a global health priority [ 2 , 3 ] with approximately 49 million cases and 13 million sepsis-related deaths each year [ 4 , 5 , 6 ]. Beyond being acutely deadly, sepsis contributes to new and worsened physical, cognitive, and mental health problems in many survivors [ 7 , 8 ]. Early identification and treatment are critical to improving outcomes.

Citations

• Multistate Point-Prevalence Survey of Health Care–Associated Infections
• Early Palliative Care Consultation in the Medical ICU: A Cluster Randomized Crossover Trial
• Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
• Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017
• Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
• Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
• Restrictive fluids versus standard care in adults with sepsis in the emergency department (<scp>REFACED</scp>): A multicenter, randomized feasibility trial
• Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit
• In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes
• Sepsis Program Activities in Acute Care Hospitals — National Healthcare Safety Network, United States, 2022
• Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis
• Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
• Sepsis and Septic Shock

Discussions

• 🚨 𝗡𝗘𝗪 𝗦𝗘𝗣𝗦𝗜𝗦 𝗚𝗨𝗜𝗗𝗘𝗟𝗜𝗡𝗘𝗦 𝗥𝗘𝗟𝗘𝗔𝗦𝗘𝗗 🚨 The 𝟮𝟬𝟮𝟲 𝗦𝘂𝗿𝘃𝗶𝘃𝗶𝗻𝗴 𝗦𝗲𝗽𝘀𝗶𝘀 𝗖𝗮𝗺𝗽𝗮𝗶𝗴𝗻 guidelines for adults and children are now available, updated with the l [bsky, 1 points, 0 comments]

Related

• Sepsis: the silent killer we should be stopping
• Surviving Sepsis Campaign Research Priorities 2023
• The Evolving Definition of Sepsis
• Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021
• Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026