Directing alendronate structures into 2-D layers with bulky quaternary phosphonium cations

2026/01/01 by Craig M. Forsyth, Glen B. Deacon, Peter Courtney Junk · 1 voice
Medicine · Environmental Science · Materials Science · #Bone health and treatments #Chemical Synthesis and Characterization #Dendrimers and Hyperbranched Polymers

paper · doi:10.1039/d5ce01121c

openalex publication_date 2026/01/01 · openalex created_date 2026/01/14 · openalex updated_date 2026/06/22

Abstract

Bisphosphonates, such as alendronate, are therapeutic agents for osteoporosis. We present new salts of alendronate anions with phosphonium cations wherein diverse supramolecular properties leads to 2-D layered materials having excellent solubility.

Citations

• Phosphonium-Based Ionic Liquids: An Overview
• van der Waals Volumes and Radii
• Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs

Discussions

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