2026/02/01 by Kwangwoo Kim, Dillon Claybaugh, Eduardo Patino Martinez +34 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #SARS-CoV-2 and COVID-19 Research #Multiple Sclerosis Research Studies #vaccines and immunoinformatics approaches
paper · pdf · doi:10.3899/jrheum.2025-0770
openalex publication_date 2026/02/01 · openalex created_date 2026/02/03 · openalex updated_date 2026/07/22
Objective The efficacy of nucleic acid–based vaccines against SARS-CoV-2 varies across individuals, partly due to genetic factors influencing neutralizing antibody production. In patients with systemic autoimmune diseases (SADs), this response may be further altered by immune dysregulation. Methods We conducted a genome-wide association study (GWAS) to identify genetic variants associated with postvaccination anti–SARS-CoV-2 IgG antibody levels and to assess whether these associations differ between patients with SAD and healthy individuals. Results The study included 165 participants (138 with SADs, 27 healthy controls), all of whom received nucleic acid–based vaccines. Antibody levels targeting the spike protein receptor-binding domain (RBD) and nucleocapsid were measured between 1 and 12 months after vaccination. GWAS results were metaanalyzed with data from a previously published GWAS with 1076 healthy individuals. We identified a novel association near RACGAP1 (rs706785; β meta = −0.30, P meta = 3.85 × 10 −8 ) and replicated a known association at HLA-DRB1 position 71 (β meta = −0.23, P meta = 1.94 × 10 −11 ). No significant interactions were observed between genotype and disease status. Conclusion This study highlights both MHC and non-MHC genetic contributions to SARS-CoV-2 vaccine responses and suggests these effects are consistent across patients with SADs and healthy individuals, supporting standard vaccination strategies for individuals with systemic autoimmune conditions.