2025/01/01 by Man Zhang, Zexin Wang, Zhihao Yu +3 · 1 voice
Medicine · #Helicobacter pylori-related gastroenterology studies #Microscopic Colitis #Whipple's Disease and Interleukins
paper · doi:10.1016/j.dcit.2025.100062
openalex publication_date 2025/01/01 · openalex created_date 2025/11/06 · openalex updated_date 2026/08/01
A primary cause of peptic ulcer, gastric carcinoma, and chronic gastritis is the Gram-negative pathogenic bacteria Helicobacter pylori ( H. pylori ). Grasping its mechanisms of pathogenesis and transmission pathways is critical for disease prevention, control, and therapeutic intervention. The pathogenesis of H. pylori and the currently identified transmission are outlined in this review. The three primary components of the pathogenic mechanism of H. pylori infection are the environment, the host, and the bacterium. H. pylori accomplish the processes of colonization, barrier disruption, infection, and sustained damage through elements such as adhesins and virulence factors. The immune response and genetic susceptibility of the host create favorable conditions for H. pylori invasion. The environment and gut microenvironment exert a profound influence on the successful establishment H. pylori . The transmission channels of H. pylori include horizontal transmission (Oral–Oral, Gastro-Oral, and Fecal-Oral routes) and vertical transmission (Mother-to-child). This review serves as a foundational reference for preventing diseases associated with H. pylori and facilitates the progress of subsequent research in this field. • Mechanisms of pathogen-host-environment interactions of H. pylori. • The multiple modes of transmission of H. pylori are summarized. • Mother-to-child transmission may be a main mode of transmission in the family. • Provide theoretical references to clarify the transmission route of H. pylori.