Severity-dependent atrial remodeling and atrial fibrillation vulnerability in a clinically relevant aortic regurgitation mouse model

2026/03/12 by Robert Lakin, Xueyan Liu, Dana Sherrard +6 · 1 voice
Medicine · #Atrial Fibrillation Management and Outcomes #Cardiac Fibrosis and Remodeling #Cardiac Valve Diseases and Treatments

paper · pdf · doi:10.1172/jci.insight.200770

openalex publication_date 2026/03/12 · openalex created_date 2026/03/20 · openalex updated_date 2026/07/27

Abstract

Severity of aortic regurgitation correlates with atrial stretch and fibrillation. Uncovering stretch-mediated atrial remodeling prior to ventricular pathology will help define optimal timing of interventions.

Citations

• 2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Discussions

• This Research Letter showcases an innovative murine model of aortic regurgitation: doi.org/10.1172/jci.... Peter H. Backx & team use a model for graded aortic regurgitation and find the severity of A [bsky, 1 points, 1 comments]

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