Micranthin B alleviates metabolic dysfunction-associated steatohepatitis by targeting G3BP1 to improve stress granule-mediated endoplasmic reticulum stress

2026/05/28 by Yang Cheng, Jingyi Wang, Mengmeng He +6 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Endoplasmic Reticulum Stress and Disease #Liver Disease Diagnosis and Treatment #Silymarin and Mushroom Poisoning

paper · doi:10.1016/s1875-5364(26)61189-2

openalex publication_date 2026/05/28 · crossref created 2026/05/28 · crossref deposited 2026/05/28 · crossref indexed 2026/05/28 · openalex created_date 2026/05/29 · crossref issued 2026/06/01 · crossref published 2026/06/01 · crossref published-print 2026/06/01 · openalex updated_date 2026/07/23

Citations

• G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Discussions

• New MASH target! 🧪 CJNM research identifies Micranthin B (MB) from Isodon lophanthoides as potent intervener. Targets G3BP1, inhibits stress granules, alleviates ER stress. Promising for metabolic [bsky, 1 points, 0 comments]