Multi-Scale Genetic and Transcriptomic Analyses Identify Druggable Targets for Epilepsy

2026/04/21 by Gao-yang Zhong, Cong Liu, Huiling Wang +3 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Epilepsy research and treatment #Genetic Associations and Epidemiology #Single-cell and spatial transcriptomics

paper · doi:10.1007/s11596-026-00194-9

crossref issued 2026/04/21 · crossref published 2026/04/21 · crossref published-online 2026/04/21 · openalex publication_date 2026/04/21 · crossref created 2026/04/21 · openalex created_date 2026/04/22 · crossref published-print 2026/06/01 · crossref deposited 2026/06/29 · crossref indexed 2026/06/29 · openalex updated_date 2026/07/29

Citations

• Inference and analysis of cell-cell communication using CellChat
• Advances in Therapy for Refractory Epilepsy
• GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy

Discussions

• Multi-scale integration of #eQTL, #GWAS & #Transcriptomics reveals FGFR3-driven FGF signaling as a principal axis in #epilepsy, highlighting #FGFR3 & HAGH as therapeutic targets. #medsky To read: doi [bsky, 1 points, 0 comments]