2026/01/01 by Guilherme Fernandes, Seong Heun Kim, Charlotte K. Hind +6 · 1 voice
Engineering · Materials Science · Medicine · #Nanoplatforms for cancer theranostics #Photochromic and Fluorescence Chemistry #Photodynamic Therapy Research Studies
paper · doi:10.1039/d6md00096g
openalex publication_date 2026/01/01 · openalex created_date 2026/05/05 · openalex updated_date 2026/07/09
-enriched states, with up to 32-fold reductions in MICs. Molecular dynamics simulations correlated these changes with light-dependent differences in membrane insertion depth and molecular orientation, providing a structural basis for optical control of membrane disruption. These findings establish a mechanistic framework for designing photoswitchable amphiphiles that translate molecular photoisomerisation into controllable biological function, extending the reach of photopharmacology into antibacterial membrane-active agents.