Copper-catalyzed xanthine–chalcogenide hybrids: synthesis, DNA binding and docking

2026/01/01 by Clara Holthausen, Isabella Barbosa dos Reis Carlos, Suzane Quintana +11 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic C–H Functionalization Methods #Organoselenium and organotellurium chemistry #Sulfur-Based Synthesis Techniques

paper · doi:10.1039/d6ob00464d

openalex publication_date 2026/01/01 · openalex created_date 2026/06/02 · openalex updated_date 2026/07/23

Abstract

Copper-catalyzed C–H chalcogenylation of xanthines with diaryl dichalcogenides affords novel hybrids; electron-withdrawing groups enhance reactivity, and selected compounds show strong DNA intercalation with favorable ADME/Tox profiles.

Citations

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