Bridging paradoxes in recombination at NLR cluster: A structural genomics perspective

2026/06/19 by Gianluca Teano, alexandre roudaut, Ariane Gratias +1 · 1 voice
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Chromosomal and Genetic Variations #DNA Repair Mechanisms #Plant-Microbe Interactions and Immunity

paper · doi:10.1016/j.pbi.2026.102908

openalex publication_date 2026/06/19 · openalex created_date 2026/06/20 · openalex updated_date 2026/07/31

Abstract

The paradox of recombination within NLR resistance gene clusters lies in the observation that these loci can exhibit either pronounced suppression or, conversely, unusually high rates of meiotic recombination, profoundly influencing allelic diversity and the evolutionary trajectory of plant immunity clusters. In recent years, progress in genome sequencing has provided novel insights into the breadth of structural variation at NLR clusters, shedding new light on these seemingly contradictory results. This review highlights recent technological advances that have enabled large-scale sequencing of complex NLR clusters, revealing previously hidden structural variation. We illustrate these findings with selected examples of NLR clusters from diverse plant species. Finally, we discuss the impact of structural variation on meiotic recombination within NLR clusters.

Citations

• The NLR-Annotator Tool Enables Annotation of the Intracellular Immune Receptor Repertoire
• Haplotype-resolved de novo assembly using phased assembly graphs with hifiasm
• De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes
• The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from <i>Arabidopsis</i> to crops
• The I gene defines a dynamic NLR cluster conferring broad potyvirus resistance in common bean
• Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors

Discussions

• Have a look at our review “Bridging paradoxes in recombination at NLR cluster: A structural genomics perspective” out in Current Opinion in Plant Biology doi.org/10.1016/j.pb... [bsky, 1 points, 0 comments]

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