2025/06/11 by Samuel Liebana Garcia, Aeron Laffere, Chiara Toschi +9 · 1 voice
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neural dynamics and brain function #Receptor Mechanisms and Signaling #Memory and Neural Mechanisms
paper · pdf · doi:10.1016/j.cell.2025.05.025
openalex publication_date 2025/06/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26
Striatal dopamine plays fundamental roles in fine-tuning learned decisions. However, when learning from naive to expert, individuals often exhibit diverse learning trajectories, defying understanding of its underlying dopaminergic mechanisms. Here, we longitudinally measure and manipulate dorsal striatal dopamine signals in mice learning a decision task from naive to expert. Mice learning trajectories transitioned through sequences of strategies, showing substantial individual diversity. Remarkably, the transitions were systematic; each mouse's early strategy determined its strategy weeks later. Dopamine signals reflected strategies each animal transitioned through, encoding a subset of stimulus-choice associations. Optogenetic manipulations selectively updated these associations, leading to learning effects distinct from that of reward. A deep neural network using heterogeneous teaching signals, each updating a subset of network association weights, captured our results. Analyzing the model's fixed points explained learning diversity and systematicity. Altogether, this work provides insights into the biological and mathematical principles underlying individual long-term learning trajectories.