TOR signaling on membranes

2025/09/19 by Robbie Loewith, Lucas Tafur · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Coagulation, Bradykinin, Polyphosphates, and Angioedema #PI3K/AKT/mTOR signaling in cancer #Protein Kinase Regulation and GTPase Signaling

paper · doi:10.1002/1873-3468.70171

openalex publication_date 2025/09/19 · openalex created_date 2025/09/20 · openalex updated_date 2026/07/12

Abstract

The Target of Rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism through two distinct complexes, TORC1 and TORC2. Each complex regulates different downstream targets; however, both are activated and regulated on lipid membranes. In this Perspective, we will revise the structural biology of TOR complexes and the molecular mechanisms governing their regulation, highlighting the importance of lipid membranes for their function.

Citations

• A conformational change in the N terminus of SLC38A9 signals mTORC1 activation
• High-confidence 3D template matching for cryo-electron tomography
• The mTORC2 signaling network: targets and cross-talks

Discussions

• The TOR pathway is a master regulator of cell growth and #metabolism. Here, Robbie Loewith and Lucas Tafur revisit the #StructuralBiology of TOR Complexes 1 and 2, highlighting how lipid #membranes se [bsky, 1 points, 0 comments]

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