Identification of Cu–OOH during the Cu–Aβ reaction with oxygen: mechanistic insights into amyloid β peptide fibrillization in Alzheimer's disease

2025/11/19 by Wooyeol Ryu, Donghwa Lee, Sugyeong Hong +6 · 1 voice
Medicine · Nursing · #Alzheimer's disease research and treatments #Vitamin C and Antioxidants Research #Trace Elements in Health

paper · doi:10.1039/d5qi02016f

openalex publication_date 2025/11/19 · openalex created_date 2025/11/19 · openalex updated_date 2026/06/11

Abstract

17 O ESEEM spectroscopy identifies the Cu–OOH intermediate formed during the Cu–Aβ–O 2 reaction with ascorbate. Integrated EPR and kinetic analyses elucidate the mechanisms of metal ion-mediated oxidative stress and amyloid fibrillization.

Discussions

• Research article by Sun Hee Kim's team. #KBSI Authors employed advanced electron paramagnetic resonance (EPR) spectroscopy to investigate the Cu–Aβ1–16–O₂ reaction and observed substantial ligand rea [bsky, 1 points, 0 comments]

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