2025/06/26 by Hannah LaRoy, Michael Thatcher, Lisa Lorenz +3 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · #Advanced Chemical Sensor Technologies #Spectroscopy Techniques in Biomedical and Chemical Research #Spectroscopy and Chemometric Analyses
paper · doi:10.1177/00037028251345820
openalex publication_date 2025/06/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
This study assessed the feasibility of using portable infrared and handheld Raman devices for the rapid screening of alcohol-based gel hand sanitizers to detect potential adulteration or misbranding. Alcohol potency was estimated by analyzing the concentration-dependent hydrogen bond-induced peak shifting characteristic of alcohol-water mixtures. Specifically, alcohol concentration in water (v/v%) was plotted as a function of the ratio of two characteristic peak positions affected by this shifting, yielding linear responses between 30%-100% for infrared spectroscopy and 40%-100% for Raman spectroscopy. Calibration equations derived from these curves were applied to estimate alcohol concentration, resulting in average errors (± standard deviations) of 1.6% (1.2%) for infrared spectroscopy and 2.4% (1.7%) for Raman spectroscopy, compared to gas chromatography with flame ionization detection (GC-FID). A total of 24 products were analyzed using this screening workflow, with results used to prioritize samples for further analysis via official compendial methods. All 21 samples identified as violative or presumptively violative by the rapid screening devices were confirmed as violative using GC-FID, while all three samples classified as presumptively non-violative were confirmed as non-violative. This method may be suitable for field deployment at locations such as mail facilities, points of entry, and express courier hubs, where expedited screening of these products is beneficial. Its implementation could enhance regulatory enforcement efforts and support consumer safety by identifying non-compliant products more efficiently.