Targeting extrachromosomal DNA in human cancers

2026/02/03 by Ivy Tsz-Lo Wong, Hyerim Yi, Bruno Melillo +3 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Advanced biosensing and bioanalysis techniques #Cancer Genomics and Diagnostics #Epigenetics and DNA Methylation

paper · doi:10.1038/s41573-025-01369-0

crossref issued 2026/02/03 · crossref published 2026/02/03 · crossref published-online 2026/02/03 · openalex publication_date 2026/02/03 · crossref created 2026/02/03 · openalex created_date 2026/02/04 · crossref published-print 2026/05/01 · crossref deposited 2026/05/07 · crossref indexed 2026/05/07 · openalex updated_date 2026/07/27

Citations

• EcDNA-borne structural variants drive oncogenic fusion transcript amplification
• The evolutionary dynamics of extrachromosomal DNA in human cancers
• Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers
• Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
• The cGAS–STING pathway as a therapeutic target in inflammatory diseases
• Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
• Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
• Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN -Amplified Cancers
• Origins and impact of extrachromosomal DNA

Discussions

• 🧬 New #ecDNA @natrevcancer.nature.com review by team #eDyNAmiC @stanfordmedicine.bsky.social @scripps.edu 👉 doi.org/10.1038/s415... Funded by: @cancerresearchuk.org #TheNationalCancerInstitue, # [bsky, 1 points, 0 comments]