The science of psychedelic medicine

2026/02/01 by Joshua S. Siegel, Conor Liston, Ginger E. Nicol +2 · 1 voice · 11 citations
Neuroscience · Pharmacology, Toxicology and Pharmaceutics · Psychology · #Action (physics) #Clinical science #Clinical trial #Forensic Toxicology and Drug Analysis #Function (biology) #Hallucinogen #MEDLINE #Neural activity #Pain Management and Placebo Effect #Precision medicine #Psychedelics and Drug Studies #Therapeutic window

paper · doi:10.1038/s41591-025-04194-5

published in Nature Medicine 32(2), 449-462 (Nature Portfolio)

crossref issued 2026/02/01 · crossref published 2026/02/01 · crossref published-print 2026/02/01 · openalex publication_date 2026/02/01 · crossref published-online 2026/02/06 · crossref created 2026/02/06 · openalex created_date 2026/02/07 · crossref deposited 2026/02/22 · crossref indexed 2026/07/15 · openalex updated_date 2026/07/23

Citations

• Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
• Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects
• Safety, Tolerability, and Efficacy of Psilocybin in 9 Patients With Obsessive-Compulsive Disorder
• Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases
• A Neurotrophic Model for Stress-Related Mood Disorders
• Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
• Response of cluster headache to psilocybin and LSD
• Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial
• Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial
• REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics
• Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
• Trial of Psilocybin versus Escitalopram for Depression
• MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study
• Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study
• Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression
• Are psychedelic medicines the reset for chronic pain? Preliminary findings and research needs
• Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
• Microdosing psychedelics and the risk of cardiac fibrosis and valvulopathy: Comparison to known cardiotoxins
• On Minimizing Risk and Harm in the Use of Psychedelics
• Prolonged adverse effects from repeated psilocybin use in an underground psychedelic therapy training program: a case report
• Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder
• LSD microdosing in major depressive disorder: results from an open-label trial
• Psychedelics and collective trauma: multisystemic resilience and recovery pathways among Nova festival survivors – a qualitative study
• Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
• Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population
• Antidepressant effects of ketamine in depressed patients
• Development of a rational scale to assess the harm of drugs of potential misuse
• The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs
• Pilot study of the 5-HT 2A R agonist psilocybin in the treatment of tobacco addiction
• Drug harms in the UK: a multicriteria decision analysis
• The entropic brain - revisited
• Psychedelics Promote Structural and Functional Neural Plasticity
• Blinding and expectancy confounds in psychedelic randomized controlled trials
• Randomized trial of ketamine masked by surgical anesthesia in patients with depression
• Psilocybin desynchronizes the human brain
• Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use

Discussions

• My take: This is the strongest review of neuroscience findings to date. Lots more in the article. Read it if you want to stay up to date: doi.org/10.1038/s415... #psychedelicscience [bsky, 1 points, 0 comments]