Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes

2026/01/01 by Olivier Berteau, Magda Teixeira Nunes, Nicole Taraglio +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Energy · Neuroscience · #Metalloenzymes and iron-sulfur proteins #Neurological diseases and metabolism #Porphyrin Metabolism and Disorders

paper · pdf · doi:10.1039/d5sc04531b

openalex publication_date 2026/01/01 · openalex created_date 2026/02/25 · openalex updated_date 2026/07/27

Abstract

This review highlights the structural and mechanistic diversity of B 12 -dependent radical SAM enzymes and their evolutionary links to other B 12 -dependent enzymes.

Citations

• Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
• Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily

Discussions

• doi.org/10.1039/D5SC... [bsky, 1 points, 0 comments]

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