Polygenic risk scores and HLA class II variants are biomarkers of corticosteroid response in childhood nephrotic syndrome

2026/02/24 by Tiffany Tu, Alejandro Ochoa, Amika Sood +58 · 1 voice
Medicine · #Pregnancy and Medication Impact #Renal Diseases and Glomerulopathies #Renal Transplantation Outcomes and Treatments

paper · doi:10.1016/j.kint.2026.01.026

openalex publication_date 2026/02/24 · crossref created 2026/02/24 · openalex created_date 2026/02/25 · crossref deposited 2026/05/20 · crossref indexed 2026/05/20 · crossref issued 2026/06/01 · crossref published 2026/06/01 · crossref published-print 2026/06/01 · openalex updated_date 2026/07/31

Citations

• Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
• A genomic mutational constraint map using variation in 76,156 human genomes
• The International Genome Sample Resource (IGSR) collection of open human genomic variation resources
• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
• Next-generation genotype imputation service and methods
• Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

Discussions

• Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome doi.org/10.1016/j.kint.2026.01.026 #NephSky #MedSky #PedsNeph @dukemedschool [bsky, 1 points, 0 comments]