MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

2026/04/16 by Kaimeng Huang, Marie Eve Brault, Ke Cong +8 · 1 voice
Biochemistry, Genetics and Molecular Biology · #DNA #DNA-binding protein #Genomics and Chromatin Dynamics #Polyadenylation #Protein stability #RNA Research and Splicing #Transcription (linguistics) #Transcription factor #Wnt/β-catenin signaling in development and cancer

paper · open access · doi:10.1016/j.molcel.2026.03.032

published in Molecular Cell 86(10), 1931-1944.e9 (Elsevier BV)

openalex publication_date 2026/04/16 · crossref created 2026/04/16 · openalex created_date 2026/04/17 · crossref issued 2026/05/01 · crossref published 2026/05/01 · crossref published-print 2026/05/01 · crossref deposited 2026/06/02 · crossref indexed 2026/06/02 · openalex updated_date 2026/07/22

Citations

• Trimmomatic: a flexible trimmer for Illumina sequence data
• Spatial partitioning of the regulatory landscape of the X-inactivation centre
• The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder
• ChromaFold predicts the 3D contact map from single-cell chromatin accessibility

Discussions

• 1. A new @cp-molcell.bsky.social paper from @chowdhurylab.bsky.social that shows proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping. [bsky, 1 points, 1 comments]