Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics

2026/04/24 by Elmira Khatamsaz, Tudor M. Ionescu, Katja Keppler +4 · 1 voice
Psychology · Neuroscience · #Mental Health Research Topics #Functional Brain Connectivity Studies #Action Observation and Synchronization

paper · pdf · doi:10.1038/s42003-026-10060-y

openalex publication_date 2026/04/24 · openalex created_date 2026/04/25 · openalex updated_date 2026/07/29

Abstract

Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that impaired DMN connectivity - achieved through activation of Parvalbumin interneurons in the orbitofrontal cortex (OFC) reduces normal social behaviour.

Citations

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Discussions

• Chemogenetic activation of orbitofrontal PV interneurons disrupts default mode network connectivity and induces social and cognitive impairments, linking OFC inhibitory microcircuit dysfunction to neu [bsky, 1 points, 0 comments]

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