Higher-order dearomative [10 + 2] cycloaddition of 2-nitrobenzofurans and 2-alkylidene-1-indanones to access pentacyclic scaffolds

2026/01/01 by Lei Yang, Yu-Ting Hou, Min Zou +5 · 1 voice
Chemistry · #Catalytic C–H Functionalization Methods #Catalytic Alkyne Reactions #Synthesis and Reactivity of Heterocycles

paper · doi:10.1039/d6qo00085a

openalex publication_date 2026/01/01 · openalex created_date 2026/03/13 · openalex updated_date 2026/06/26

Abstract

A higher-order dearomative [10 + 2] cycloaddition of 2-nitrobenzofurans with in situ generated 1-hydroxyisobenzofulvene anions enables fused pentacyclic benzofurocyclopenta[b]indanones in high yields with excellent diastereoselectivity.

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