Direct arylation of gem -difluorostyrenes using in situ mechanochemically generated calcium-based heavy Grignard reagents

2024/12/24 by Xihong Wang, Yamato Fukuzawa, Pan Gao +4 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry #Inorganic Fluorides and Related Compounds

paper · pdf · doi:10.1039/d4mr00135d

openalex publication_date 2024/12/24 · openalex created_date 2024/12/25 · openalex updated_date 2026/07/13

Abstract

Calcium-based heavy Grignard reagents, prepared in situ through a mechanochemical method, reacted with gem -difluorostyrenes to afford thermodynamically less favorable ( E )-monofluorostilbenes with good to high stereoselectivity.

Citations

• Chemistry 2.0: Developing a New, Solvent-Free System of Chemical Synthesis Based on Mechanochemistry
• Mechanochemical Cross-Coupling Reactions

Discussions

• Check out the mechanochemical synthesis of calcium-based heavy Grignard reagents for the arylation of gem-difluorostyrenes in this recent article from RSC Mechanochemistry Editorial Board member Hajim [bsky, 1 points, 0 comments]

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