2026/03/24 by Owen Tsung Wen Ho, Beth Shi Yu Lim, Yah Ru Juang +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Chromatin Remodeling and Cancer #Mechanisms of cancer metastasis #Metastasis and carcinoma case studies
paper · doi:10.1017/s0022215126104605
crossref issued 2026/03/24 · crossref published 2026/03/24 · crossref published-online 2026/03/24 · openalex publication_date 2026/03/24 · crossref created 2026/03/24 · openalex created_date 2026/03/25 · crossref published-print 2026/06/01 · openalex updated_date 2026/07/14 · crossref deposited 2026/07/17 · crossref indexed 2026/07/30
OBJECTIVES: This study aims to provide an updated systematic review on the clinicopathological features, treatment modalities and survival outcomes on SMARCB1-deficient sinonasal carcinoma. METHODS: Five databases were searched: PubMed, Cochrane, Embase, Web of Science and Scopus. Extracted information include demographic data, clinicopathological characteristics and survival outcomes. RESULTS: A total of 70 studies were included making up a total of 372 patients. Univariable and multivariable analysis performed for prognostic factors of SDSC showed that N+ disease was a statistically significant poor prognostic factor for overall survival, while surgical treatment was a favourable prognostic factor. Treatment with surgery combined with chemotherapy and/or radiotherapy conferred significantly better prognosis compared to chemotherapy or radiotherapy alone. CONCLUSION: Our study suggests that N+ disease and isolated treatment with radiotherapy or chemotherapy alone are significant poor prognostic factors for SMARCB1-deficient sinonasal carcinoma, while patients who undergo surgical treatment have significantly better prognosis.