2011/07/04 by Rajita Pappu, Vladimir Ramirez-Carrozzi, Arivazhagan Sambandam · 1 citation
Immunology and Microbiology · Medicine · #IL-33, ST2, and ILC Pathways #Psoriasis: Treatment and Pathogenesis #Whipple's Disease and Interleukins
paper · doi:10.1111/j.1365-2567.2011.03465.x
crossref issued 2011/07/04 · crossref published 2011/07/04 · crossref published-online 2011/07/04 · openalex publication_date 2011/07/04 · crossref created 2011/07/04 · crossref published-print 2011/09/01 · crossref deposited 2024/04/08 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
The interleukin-17 (IL-17) cytokines, IL-17A to IL-17F, are emerging as critical players in host defence responses and inflammatory diseases. Substantial data support the role of these proteins in innate and adaptive immunity. Of these family members, IL-17A, IL-17F and IL-17E have been the best studied. Both IL-17A and IL-17F contribute to the host response to extracellular bacteria and fungi, and IL-17E has been shown to play a role in parasitic infections. In addition, numerous pre-clinical and clinical studies link these proteins to the pathogenesis of inflammatory diseases, and a number of therapeutic programmes targeting these family members are in clinical development. This review will highlight the cellular sources, receptors/target cells, and role in inflammation of these and the less-characterized family members, IL-17B, IL-17C and IL-17D.